Takayuki Morisaki Selected Research

Loeys-Dietz Syndrome

1/2022	Long-term durability of a reimplantation valve-sparing aortic root replacement can be expected in both Marfan syndrome and Loeys-Dietz syndrome.
1/2022	The differences in surgical long-term outcomes between Marfan syndrome and Loeys-Dietz syndrome.
2/2021	Surgical Outcome and Histological Differences between Individuals with TGFBR1 and TGFBR2 Mutations in Loeys-Dietz Syndrome.
1/2021	Mouse Model of Loeys-Dietz Syndrome Shows Elevated Susceptibility to Periodontitis via Alterations in Transforming Growth Factor-Beta Signaling.
10/2015	Reversible cerebral vasoconstriction syndrome and posterior reversible encephalopathy syndrome in a boy with Loeys-Dietz syndrome.
6/2014	Acute dilatation of the ascending aorta and aortic valve regurgitation in Loeys-Dietz syndrome.
11/2012	Surgical experience with aggressive aortic pathologic process in Loeys-Dietz syndrome.
5/2010	High prevalence of vertebral artery tortuosity of Loeys-Dietz syndrome in comparison with Marfan syndrome.
2/2010	Progressive aortic root and pulmonary artery aneurysms in a neonate with Loeys-Dietz syndrome type 1B.
10/2009	Mutation of ACTA2 gene as an important cause of familial and nonfamilial nonsyndromatic thoracic aortic aneurysm and/or dissection (TAAD).

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Takayuki Morisaki Research Topics

Disease

10	Loeys-Dietz Syndrome 01/2022 - 10/2009
6	Aortic Aneurysm (Aneurysm, Aortic) 06/2020 - 10/2009
5	Marfan Syndrome (Marfan's Syndrome) 01/2022 - 08/2004
5	Aneurysm (Aneurysms) 01/2020 - 02/2010
5	Insulin Resistance 12/2017 - 05/2009
4	Metabolic Syndrome (Dysmetabolic Syndrome X) 02/2012 - 12/2006
3	Cardiovascular Diseases (Cardiovascular Disease) 08/2021 - 10/2013
3	Obesity 08/2021 - 06/2008
3	Aortic Dissection 02/2021 - 12/2016
3	Ischemia 04/2013 - 06/2005
2	Familial Thoracic 1 Aortic Aneurysm 01/2022 - 10/2009
2	Disease Progression 06/2020 - 01/2020
2	Aortic Diseases 01/2020 - 12/2016
2	Pulmonary Arterial Hypertension 10/2018 - 02/2006
2	Body Weight (Weight, Body) 12/2017 - 06/2008
2	Renal hypouricemia 12/2016 - 01/2010
2	Inborn Genetic Diseases (Disease, Hereditary) 12/2016 - 06/2009
2	Clubfoot (Talipes Equinovarus) 10/2015 - 02/2010
2	Thoracic Aortic Aneurysm 04/2015 - 10/2009
2	Lung Injury 04/2013 - 04/2007
2	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 11/2011 - 12/2008
2	Reperfusion Injury 04/2007 - 06/2005
2	Neoplasms (Cancer) 09/2004 - 08/2004
1	Inguinal Hernia (Direct Inguinal Hernia) 08/2021
1	Weight Loss (Weight Reduction) 08/2021
1	Necrosis 02/2021
1	Hypoxia (Hypoxemia) 01/2021
1	Aggressive Periodontitis (Periodontosis) 01/2021
1	Periodontitis 01/2021
1	Hematologic Diseases (Blood Diseases) 10/2020
1	type C2 Niemann-Pick disease 01/2020
1	Patent Ductus Arteriosus 10/2018
1	Type 2 Diabetes Mellitus (MODY) 12/2017
1	Glucose Intolerance 12/2017
1	Cicatrix (Scar) 12/2016
1	Hypertelorism 12/2016
1	Acute Kidney Injury (Acute Renal Failure) 12/2016
1	Chromosome Deletion (Deletion, Chromosome) 02/2016
1	Supravalvular Aortic Stenosis (Aortic Supravalvular Stenosis) 01/2016
1	Pathologic Constriction (Stenosis) 01/2016
1	Moyamoya Disease (Moya-Moya Disease) 01/2016
1	Craniosynostoses (Craniosynostosis) 10/2015
1	Abdominal Aortic Aneurysm 04/2015
1	Endocarditis 09/2014
1	Rupture 09/2014
1	Mucocutaneous Lymph Node Syndrome (Kawasaki Disease) 09/2014
1	Arteriovenous Malformations (Arteriovenous Malformation) 05/2014
1	Gout 10/2013
1	Hemorrhage 04/2013
1	Chronic Obstructive Pulmonary Disease (COPD) 04/2013
1	Emphysema 04/2013
1	Anemia 11/2012
1	Pyruvate Kinase Deficiency of Red Cells 11/2012

Drug/Important Bio-Agent (IBA)

8	Transforming Growth Factor-beta Type II ReceptorIBA 02/2021 - 08/2004
6	Transforming Growth Factor-beta Type I ReceptorIBA 01/2022 - 10/2009
6	Transforming Growth Factor beta Receptors (TGF beta Receptors)IBA 02/2021 - 08/2004
5	Proteins (Proteins, Gene)FDA Link 08/2021 - 12/2008
5	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2021 - 05/2014
3	Uric Acid (Urate)IBA 12/2016 - 04/2008
3	AMP Deaminase (Myoadenylate Deaminase)IBA 12/2014 - 04/2007
2	Fibrillin-1IBA 01/2022 - 01/2020
2	ElastinIBA 08/2021 - 01/2016
2	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 06/2009
2	Transforming Growth Factor beta (TGF-beta)IBA 01/2021 - 04/2013
2	Biomarkers (Surrogate Marker)IBA 06/2020 - 01/2020
2	Glucose (Dextrose)FDA LinkGeneric 12/2017 - 12/2014
2	Ribosomal Protein S6 Kinases (S6 Kinase)IBA 12/2015 - 03/2015
2	LigandsIBA 04/2015 - 09/2004
2	Messenger RNA (mRNA)IBA 04/2013 - 04/2007
2	Adenosine Monophosphate (AMP)IBA 04/2013 - 04/2007
2	Inosine Monophosphate (IMP)IBA 04/2013 - 04/2007
2	Adenosine Triphosphate (ATP)IBA 11/2012 - 06/2005
2	AdiponectinIBA 02/2012 - 05/2009
2	Cardiac MyosinsIBA 11/2011 - 12/2008
2	Carrier Proteins (Binding Protein)IBA 11/2011 - 12/2008
2	Oxidoreductases (Dehydrogenase)IBA 08/2009 - 12/2006
2	Hormones (Hormone)IBA 05/2009 - 06/2008
1	Tyrosine (L-Tyrosine)FDA Link 08/2021
1	GlycolipidsIBA 08/2021
1	Fluorescent Dyes (Fluorescent Probes)IBA 01/2021
1	RNA (Ribonucleic Acid)IBA 01/2021
1	ProteomeIBA 01/2020
1	Thrombospondin 1IBA 01/2020
1	Insulin-Like Growth Factor Binding ProteinsIBA 01/2020
1	Arginine (L-Arginine)FDA Link 10/2018
1	FructoseIBA 12/2017
1	hydralazine 4-anisaldehyde hydrazoneIBA 07/2017
1	Urate Oxidase (Uricase)IBA 12/2016
1	Allopurinol (Remid)FDA LinkGeneric 12/2016
1	Transforming Growth Factor beta3 (TGF beta 3)IBA 04/2015
1	Pharmaceutical PreparationsIBA 12/2014
1	Metformin (Glucophage)FDA LinkGeneric 12/2014
1	Insulin (Novolin)FDA Link 12/2014
1	AntibodiesIBA 09/2014
1	Peroxidase (Myeloperoxidase)IBA 04/2013

Therapy/Procedure

2	Therapeutics 08/2021 - 12/2014
2	Ligation 02/2016 - 04/2007
1	Replantation 01/2022
1	Drug Therapy (Chemotherapy) 10/2020
1	Endovascular Aneurysm Repair 12/2017